Antistaphylococcal activity of liposomal forms of lincomycin

S Derkach; O Kotsar; N Ivanova; I Voronkyna; I Krylova

Автор(и)

S Derkach Mechnikov Institute of Microbiology and Immunology,
O Kotsar Mechnikov Institute of Microbiology and Immunology,
N Ivanova Mechnikov Institute of Microbiology and Immunology,
I Voronkyna Mechnikov Institute of Microbiology and Immunology,
I Krylova Mechnikov Institute of Microbiology and Immunology,

Ключові слова:

liposomal forms of antibiotics, lincomycin, antibiotics, sensitivity, staphylococcus

Анотація

Nowadays the vital problem of modern medicine is a tendency to emerging of both nosocomial and community-acquired strains before antibiotic resistance forming. The complexity of antibiotic therapy of diseases caused by methicillin resistant staphylococci having high poly resistance almost to every classes of antibacterial agents is of prime importance. One of the ways to improve antibacterial preparations still remains the development of their liposomal forms. This work studies anti-staphylococcal activity (according to MIC) of the liposomal form of lincomycin developed in the Institute of Dermatology and Venereology of Ukraine by Ivanova N. N., the Candidate of Сhemical Sciences. The purpose of this research work was to study liposomal inhibiting concentration of the liposomalny form of lincomycin and a commercial preparation lincomycin (produced by CJSC “Pharmaceutical firm "Darnitsa"). Determination of the minimum inhibiting concentration was carried out by a tablet micromethod by consecutive cultivations of the samples under study. It is shown that MIC of liposomal lincomycin is eight times as low as usual lincomycin (0,23mkg/ml to 1,87 mkg/ml). Antibacterial activity of the liposomal form of lincomycin is studied concerning the patients selected from the different biotopes with pyo inflammatory diseases of staphylococcus strains (15 strains –methicillin sensitive, 12 strains - methicillin resistant). It is shown authentically the higher sensitivity of S. aureus strains to the liposomal form of lincomycin in comparison with usual lincomycin . Also 50.0% of MRSA strains were sensitive to the liposomalny form of lincomycin that shows the perspective for the development of the liposomal forms of antibiotics to cure staphylococcal infections.

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