Antagonism of A. viridans to conditionally - pathogenic microflora of the nose and oropharynx of children with cardiac patology

D Stepansky

Автор(и)

D Stepansky Dnipropetrovsk Medical Academy,

Ключові слова:

Aerococcus viridans, probiotics, autostrains of aerococcuses, children.

Анотація

Introduction. Search forharmlessand simultaneouslyeffectiveprobiotics, which could be successfully usedfor treatmentand prevention of infectious deseases, is currently important. A. viridansis of particular interest, as it isrepresentative of thenormal microfloraof human withbroad spectrum of antibacterial action.The useof this microorganismhas a numberof advantages:the absence ofsideeffects on the body; highadhesiveabilities; resistance tolysozymeinsaliva;the abilityofusein patients, sensitizedto antibiotics andchemotherapeutic drugs;stimulationeffects onthe human immune system.Material and methods. The purpose ofthe studywas to investigate theantagonism ofA. viridans №167andautostrains of aerococcuses, isolatedat patients,toconditionally -pathogenic microflora of the nose andoropharynxof children withcardiac patology. At the firststage of the studythemicroflora of theof the nose andoropharynxof 2 investigatedcategorieswas examined – 40 children4-14yearswith cardiac patology and 40healthychildren 4-5 years old. The second stage ofwork was tostudy the effect of A. viridanson the exploredstrains. Results and discussion. A. viridansmanifeststhe antagonism to allstudiedstrains ofgram-positiveandgram-negativemicroorganisms,except C.albisans. A. viridansantagonistic activitytostaphylococci(10 +3 mm) and streptococci(10 +2mm) is at the approximatelysamelevel. It is interestingtocompare theantagonism ofaerococcusesto clinicalisolates ofS. pyogenesand similarstrainsfromcarriers (healthy children category). Impactof aerococcuses on P. mirabilisstrainappearedat the highestlevel. Autosimbionts ofA. viridans,isolated fromhealthy children,are moreantagonistic toCPMstrains,isolatedfrom thesechildren, thanautostrains ofA. viridans,isolated fromchildren withwith cardiac patology, and higher thanthe museumstrainofA. viridans №167 antagonism, and do not affectthe growth of microorganisms of Candidakind. Severeantagonistic activityof the A. viridans №167 strainandautostrains of A. viridans to isolatedconditionally patogeneticstrains was discovered: S. pyogenes, S. pneumoniae, S. aureus, K. pneumoniae, P. mirabilis.Antagonism ofA. viridans №167 to C.albicanswas notfound. Conclusion. The recieved datacanserve as a basisfor further study of the strain of A. viridans №167andaerococcuses’ autostrainsusage for correction of fauces and nasopharynxmicrobiocenosis and also for the complextreatment andpreventive actions in case of cardiac pathology.

Посилання

Autoprobiotics as means of infectious and inflammatory diseases prevention in humans in an artificial environment / V.К. Ilyin, A.N. Suvorov, N.V. Kirukhina [et al.] [Text] // Bulletin of Medical Sciences. – 2013. – Vol. – 2. - P. 56–62.

Kremenchutsky, G.N. Role of the human body microecology and the principles of its correction [Text] / G.N. Kremenchutsky, S.A. Rizhenko, S.I. Polishchuk. - Dnepropetrovsk, 2003. – P. 58–59.

Recommendations for the prevention, diagnosis and treatment of infective endocarditis [Text] // Ukr. cardiological magazine. – 2004. – Vol. – 4. – P. 115–121.

Ryzhenko, S.A. A-bacterin – new probiotic. – Dnepropetrovsk: Porohy, 2001. – 252 p.

Order of the USSR Ministry of Health number 535 of 04/22/85. "About the unification of microbiological research methods used in clinical diagnostic laboratories of health facilities".

Soboleva, M.K. Primary infectious endocarditis in children and adolescents [Text] / M.K. Soboleva, E.G. Sobolev, M.E. Skoblyakova // Pediatrics. – 2006. – Vol. 2. – P. – 11–17.

Shyrobokov V. P. New strategies in the development and clinical use of probiotics [Text] / V.P. Shyrobokov, D.S. Jankowski, G.S. Dyment // Bulletin of pharmacology and pharmacy. – 2010. – Vol. 2. – P. 18-30.