Heterogeneity of Staphylococcus population on the basis of methicillin resistance

O Kotsar; I Voronkina; S Derkach; I Krylova; L Gabisheva

Автор(и)

O Kotsar Mechnikov Institute of Microbiology and Immunology,
I Voronkina Mechnikov Institute of Microbiology and Immunology,
S Derkach Mechnikov Institute of Microbiology and Immunology,
I Krylova Mechnikov Institute of Microbiology and Immunology,
L Gabisheva Kharkov National Medical university,

Ключові слова:

staphylococcal infection, metytsylin resistance, heterogeneity.

Анотація

57 Staphylococcus strains were identified and excluded from patients. Metytsylin resistance of these strains was determined using disc-diffusion method and method of serial dilutions with oxacillin MIC determination. In in vitro studies of heterogeneity for the cultures with metytsylin resistance was revealed. Expression of heterogeneity was shown to be more typical for strains with low and average levels of oxacillin MICs.

Посилання

Kuchma, I. U. Heterogeneity on the criteria of biological properties and sensitivity to antimicrobial agents bacteria of the genus Streptococcus vegetating in the respiratory system of patients with pneumonia [Text] / I. U. Kuchma // Infectious diseases. – 2013. -

№ 1. – P. 69-73.

Volianskiy, U. L. SOS literally and figuratively. New strategy to combat the development of resistance to antibiotics [Text] / U. L. Volianskiy, T. U. Kotlova, І. U. Kuchma // Teoretichna medicine. –

– t. 19, No 2. – P. 162–170.

Microbiological study of the principle of creating complex of preventive antimicrobial properties on the formation of antibiotic resistance [Text] / N. Filimonov [et al.] / / Journal of Pharmacy. - 2005. - № 1 (41). - P. 69-72.

Guidelines for the use of standardized microbiological (bacteriological) methods in clinical diagnostic laboratories [Text] / Application number 1 to the order of the USSR Ministry of Health number 535 of 22 April 1985 - 45 c.

Order № 167 On approval of guidance “given the sensitivity of microorganisms to antibiotics” MOH (Ministry of Health) of Ukraine of 05.04.2007 : [Text] / . – access mode: http://mozdocs.kiev.ua.

Moellenng, R. C. Community-acquired methicillinresistant Staphylococcus aureus: no longer confined to the inpatient arena [Text] / R. C. Moellenng // Infect. Dis. Special Edition. – 2003. – №6. – P. 63–67.

Overview of the British guidenlines on the management of CA-MRSA infections. [Text] / A.A. Nikulin, A.V. Dekhich. // Clinical Microbiology and Antimicrobial Chemotherapy. – 2010. - V.12 - № 1. -

P. 4–22.

Lederberg, J. 50 eves. Orvosi Hetilap [Text] / J. Lederberg. – 1975. – № 116(36). – Р. 2135–2136.

Lapach, SM Statistical methods in biomedical studies using Excel [Text] / SM Lapach, AV Tschubenko, P. Babich. - K.: "MORІON", 2001 - 408 p.

Glantz, S. Biomedical Statistics [Text] / Per. from English. - M.: Practice, 1998. - 459 p.

Paliy, V. G. Research of antimicrobial properties based on composition of detametaksin. / V. G. Paliy [et al.] // Naukoviy visnik Uggorodckogo university serious «Medcine». – 2012. – vol. 1 (43) – P. 48-52.

Kutcyk, R. V. Microbiological study new approaches to the treatment and prevention of stafphylococcal infection based on a study of antimicrobial properties of thiazole derivatives, furan, acridine and biologically actives substances of natural origin: Avtiref.dys … Dr. of Medical Science: 03.00.07 / state enterprise “Inst. microbial. and

immunol. im. I.I. Mechniykova Science of Ukraine.” –

Kharkov, 2008. – P 40.