Macromicroscopic changes of the laboratory rats kidney in norm and after immunocomprometation with enterococcus infection

I Torianik; L Myronenko; E Peretyatko; I Tkachyk

Автор(и)

I Torianik Mechnikov Institute of Microbiology and Immunology,
L Myronenko Mechnikov Institute of Microbiology and Immunology,
E Peretyatko Mechnikov Institute of Microbiology and Immunology,
I Tkachyk Institute of Neurosurgery after name acad. AP Romodanov National Academy Medical Sciences of Ukraine,

Ключові слова:

pathomorphological changes, experimental enterococcus infection, laboratory female rats (Wistar), kidney, nephropathy, inflammatory (alterative) processes.

Анотація

The unification approach to the creation of the enterococcus infection model in the unlinear immunocomprometive laboratory female rats (Wistar) is presented in the article. The examinational material are in the female rats (of the 3-th- months age’s (n=60), the 165-170 g by weight). The purpose of the experiment’s are achieving by the seding enterococcus infection means of the basic structures and blood vessels of the kidney, digestive system damages, that similar with the such in a human in a case of the development of a traditional clinic pathology. The results are evaluated to character of the morphological changes (destructive and degenerative alterations, necrosis, nephropathy, inflammatory (alterative) processes. Sum upping, of capable of the achievement, we are noting carried out experiment’s efficiency and the using optimistic perspective of the extrapolative data in the capacity as a foundation for the further of the newest methods of the enterococcus infection.

Посилання

Аbramov М. G. Gematological atlas [Теxt] / М. G. Аbramov // М. – Меdicina - 3-d ed. - 2005. - 116 p.

Contribution of individual Ebp Pilus subunits of Enterococcus faecalis OG1RF to pilus biogenesis, biofilm formation and urinary tract infection [Text] / Jouko Sillanpaa [et al.] // PloS one. – 2013. – No 8 (7). – P. – 68813.

Dati F. New Aspects of Laboratory Testing for Hemostasis Disorders [Text] / F. Dati //Journal of Laboratory and Clinic – Medicine. - 2006. - Vol. 8, No 3. - P. 9 - 11.

Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals [Text] / D. Panesso [et al.] // J. Clin. Microbiol. – 2010. – No 48. – P. 1562–1569.

Nаzаrenko G. I. Clinical mark of the laboratory examination resalts [Теxt] /G. I. Nаzаrenko, А. А. Кishkun // М. – Меdicina - 2-d ed.- 2002. - 544с.

Singh K. V. Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model [Text] / K. V. Singh, B. E. Murray // Antimicrobial agents and chemotherapy. – 2012. – No 56 (6). – P. – 3457–3460

Теlеgin L. Yu. Experimental pharmacogenetics of cyclophosphamid [Теxt]: Аvtoref. of manuscr. by L.Yu. Теlеgin Dr. Med. Sc.: 14.03.06 – Pharmacology, Clinical Pharmacology: 5.03.2011.: ed. /Leonid Yur’evich Теlеgin. - М., 2010. - 46 p.

Vozianova J. І. Infections and parasitory diseases [Теxt] / J. І. Vozianova // Кiyv – Zdorov’ya - 2001. – V. 2. – P. 656.

Willems R. J. Transition of Enterococcus faecium from commensal organism to nosocomial pathogen [Text] / R. J. Willems L. W. Schaik // Future Microbiol.– 2009.– Vol. 4. – P. 1125–1135.