Antimicrobial, physical and chemical qualities of medicinal antiseptic drugs

Анотація

In our research results of the study of antimicrobial, physical and chemical qualities of antiseptic medicines of decamethoxin (DCM). Antimicrobial activity of DCM, palisan, decasan, deseptol against srains of S.aureus (n 56), S.epidermidis (n 26), E.coli (n 24), P.mirabilis (n 11), P.vulgaris (n 8) was studied by means of method of serial dilutions. Obtained data of mass spectrometry study of antimicrobial compositions with constant concentrations of DCM have shown that medicinal forms of DCM are complex physical and chemical systems, because of different origin and number of adjuvant ingredients used during their fabrication. Among synthetic quaternary ammonium agents there have been found the substance (commercial name of medicine is decamethoxin) to have high antimicrobial activity against strains of gram-positive and gram-negative microorganisms, an also C.albicans. There was found that antimicrobial activity of antiseptic palisan had been higher comparably to DCM in equivalent concentration. The composition and concentrations of acting agents and the methodology of preparation of palisan have been substantiated on the basis of microbiological, mass spectrometry characteristics of antiseptics DCM, palisan.