Comparison of chemical composition and antioxidant activity from fresh and dried osage orange (Maclura pomifera) fruits extracts

Автор(и)

  • Олександр Маслов Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0000-0001-9256-0934
  • Микола Комісаренко Національний фармацевтичний університет, м. Харків, Україна., Україна
  • Сергій Колісник Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0000-0002-4920-6064
  • Соломія Себій Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0009-0002-5150-9811
  • Тетяна Костіна Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0000-0002-5985-3847
  • Валерій Мороз Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0000-0003-3392-9636
  • Елшан Ахмедов Національний фармацевтичний університет, Харків, Україна, Україна https://orcid.org/0000-0001-6727-8259

DOI:

https://doi.org/10.5281/zenodo.8324881

Анотація

Introduction. Osage orange fruit is perspective raw material for developing new medicines with antioxidant and antibacterial properties. In pharmacy for obtaining tincture, infusion and extracts use only dried raw material, but there is question about influence fresh raw material on content of phenolic compounds and pharmacological properties of tincture, infusion and extracts. The aim of work was comparison of chemical composition and antioxidant activity from fresh and dried osage orange (Maclura pomifera) fruits extracts. Materials & methods. The object of the study osage orange fresh and dried fruits. The extracts were prepared using 96, 60, 40, 20% (v/v) ethanol and distilled water. The number of phenolic compounds, flavonoids, and hydroxycinnamic acids was determined by a spectrophotometric analysis method, whereas the antioxidant activity of obtained extracts was evaluated by potentiometric method. Results & discussions. The highest content of phenolic compounds (0.70±0.02% and 0.50±0.02%) and flavonoids (0.39±0.02% and 0.29±0.02%) was in 60% ethanolic M. pomifera fresh and dried fruits extracts, respectively, while amount of hydroxycinnamic acids (0.60±0.02% and 0.41±0.02%) and value of dry residue (11.93±0.12% and 8.59±0.09%) were dominated in 40% M. pomifera fresh and dried fruits ethanolic extracts, respectively. The 60% M. pomifera fresh (70.10±1.40 mmol-equiv./mdry weight) and dried (48.11±0.96 mmol-equiv./mdry weight) fruits extracts had the highest level of antioxidant activity among other extracts. The content of biologically active substances and antioxidant were higher in the M. pomifera fresh fruits extracts than in dried ones. The correlation analysis showed that there was a very high positive correlation of antioxidant activity and total phenolic compounds content, high correlation – total flavonoid, hydroxycinnamic acids content and there was no correlation in case of dry residue. Conclusions. The 60% ethanol is the most appropriate solvent to extract the highest amount of phenolic compounds from osage orange fruits. The extracts from fresh raw material has high content of biologically active substances and antioxidant activity than from dried raw material. The phenolic compounds are the main contribute to the antioxidant activity of osage orange fruits extracts. Thus, the fresh osage orange fruits should be use in the developing and creating phytomedicines with antioxidant property.

Key words: Osage orange, fresh and dried fruits, extracts, phenolic compounds, antioxidant activity, correlation

Біографії авторів

Олександр Маслов, Національний фармацевтичний університет, Харків, Україна

доктор філософії, асистент каф. аналітичної хімії та аналітичної токсикології

Микола Комісаренко , Національний фармацевтичний університет, м. Харків, Україна.

канд. фарм. наук, асистент каф. фармакогнозії

Сергій Колісник, Національний фармацевтичний університет, Харків, Україна

д-р фарм. наук, професор, зав. каф. аналітичної хімії та аналітичної токсикології

Соломія Себій, Національний фармацевтичний університет, Харків, Україна

студентка 4 курсу

Тетяна Костіна, Національний фармацевтичний університет, Харків, Україна

канд. фарм. наук, доцент каф. аналітичної хімії та аналітичної токсикології

Валерій Мороз, Національний фармацевтичний університет, Харків, Україна

канд. фарм. наук, доцент каф. аналітичної хімії та аналітичної токсикології

Елшан Ахмедов, Національний фармацевтичний університет, Харків, Україна

канд. фарм. наук, доцент каф. аналітичної хімії та аналітичної токсикології

Посилання

Maslov OY, Kolisnyk SV, Komisarenko MA, Altukhov AA, Dynnyk KV, Stepanenko VI. Study and evaluation antioxidant activity of dietary supplements with green tea extract. Curr Issues Pharm Med. 2021. 14(2). 215-219. DOI: 10.14739/2409-2932.2021.2.233306

Maslov O, Kolisnyk S, Komisarenko M, Golik M, Antonenko O. Study of chemical composition and antioxidant activity of tincture, infusion of green tea leaves. Fitoterapia. 2022. (1). 48-52. DOI: 10.33617/2522-9680-2022-1-48

Maslov OY, Komisarenko MA, Kolisnyk SV, Golik MY, Tsapko YO, Akhmedov EY. Determination of the extraction frequency of green tea leaves by the antioxidant method. J Org Pharm Chem. 2022. 20(1(77)). 28-34. DOI: 10.24959/ophcj.22.252320

Darji K, Miglis C, Wardlow A, Abourashed EA. HPLC Determination of Isoflavone Levels in Osage Orange from the Midwest and Southern United States. J Agric Food Chem. 2013. 61(28). 6806-6811. DOI: 10.1021/jf400954m

Saloua F, Eddine NI, Hedi Z. Chemical composition and profile characteristics of Osage orange Maclura pomifera (Rafin.) Schneider seed and seed oil. Ind Crop Prod [Інтернет]. 2009. 29(1). 1-8. DOI: 10.1016/j.indcrop.2008.04.013

Su Z, Wang P, Yuan W, Grant G, Li S. Phenolics from the Fruits of Maclura pomifera. Nat Prod Commun. 2017. 12(11). 1934578X1701201. DOI: 10.1177/1934578x1701201122

Gajić I, Dinić A, Stanojević L, Zvezdanović J, Nikolić V, Urošević M, Nikolić L, Savić V. Osage orange (Maclura pomifera (Raf.) Schneid) fruit extracts: UHPLC-DAD-ESI-MS/MS analysis, antioxidant activity and in vivo skin tests. Nat Prod Res. 2023.1-6. DOI: 10.1080/14786419.2023.2208361

Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA. Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia. 2021. 68(4). 731-739. DOI: 10.3897/pharmacia.68.e70180

da Costa CT, Dalluge JJ, Welch MJ, Coxon B, Margolis SA, Horton D. Characterization of prenylated xanthones and flavanones by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. J Mass Spectrom. 2000. 35(4). 540-549. DOI: 10.1002/(sici)1096-9888(200004)35:4%3C540::aid-jms966%3E3.0.co;2-y

Battaloglu R. Determination of Essential Oils Components of Maclura pomifera (Osage Orange) Fruit from Turkey. Int J Second Metab. 2017. 459-462. DOI: 10.21448/ijsm.376898

Lee SJ, Ahmed AA, Wood A, Mabry TJ. New Lupane Triterpene Fatty Acid Ester from Leaves of Maclura pomifera. Nat Prod Lett. 1997. 10(4). 313-317. DOI: 10.1080/10575639708043746

Peterson C, Fristad A, Tsao R, Coats JR. Osajin and Pomiferin, Two Isoflavones Purified from Osage Orange Fruits, Tested for Repellency to the Maize Weevil (Coleoptera: Curculionidae). Environ Entomol. 2000. 29(6). 1133-1137. DOI: 10.1603/0046-225x-29.6.1133

Canli K, Bozyel ME, Altuner EM. In Vitro antimicrobial activity screening of maclura pomifera fruits against wide range of microorganisms. Int J Pharm Sci Inv. 2017. 6(8). 19-22.

Moon HI, Kim YB, Kim SK. Anti-influenza A activity of C-geranyl flavonoids isolated from Paulownia tomentosa and Maclura pomifera. Bulg Chem Com. 2016. 48(2). 303-305.

Khaleghi A, Naderi R, Brunetti C, Maserti BE, Salami SA, Babalar M. Morphological, physiochemical and antioxidant responses of Maclura pomifera to drought stress. Sci Rep. 2019. 9(1). DOI: 10.1038/s41598-019-55889-y

Yang R, Hanwell H, Zhang J, Tsao R, Meckling KA. Antiproliferative Activity of Pomiferin in Normal (MCF-10A) and Transformed (MCF-7) Breast Epithelial Cells. J Agric Food Chem. 2011. 59(24). 13328-13336. DOI: 10.1021/jf202898g

Kupeli E, Orhan I, Toker G, Yesilada E. Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. J Ethnopharmacol. 2006. 107(2). 169-174. DOI: 10.1016/j.jep.2006.02.021

Florian T, Necas J, Bartosikova L, Klusakova J, Suchy V, Naggara EB, Janostikova E, Bartosik T. Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006.150(1). 93-100. DOI: 10.5507/bp.2006.013

Orhan I, Şenol FS, Kartal M, Dvorská M, Žemlička M, Šmejkal K, Mokrý P. Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider. Food Chem Toxicol. 2009. 47(8). 1747-1751. DOI: 10.1016/j.fct.2009.04.023

Kozłowska M, Ścibisz I, Przybył J, Ziarno M, Żbikowska A, Majewska E. Phenolic Contents and Antioxidant Activity of Extracts of Selected Fresh and Dried Herbal Materials. Pol J Food Nutr Sci. 2021. 269-278. DOI: 10.31883/pjfns/139035

Calín-Sánchez Á, Lipan L, Cano-Lamadrid M, Kharaghani A, Masztalerz K, Carbonell-Barrachina ÁA, Figiel A. Comparison of Traditional and Novel Drying Techniques and Its Effect on Quality of Fruits, Vegetables and Aromatic Herbs. Foods. 2020. 9(9). 1261. DOI: 10.3390/foods9091261

Hossain MB, Barry-Ryan C, Martin-Diana AB, Brunton NP. Effect of drying method on the antioxidant capacity of six Lamiaceae herbs. Food Chem. 2010;123(1). 85-91. DOI: 10.1016/j.foodchem.2010.04.003

The State Pharmacopoeia of Ukraine: in 3 volumes, 2nd ed.; State Enterprise “Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines”: Kharkiv, 2014; Vol. 2.

Maslov OY, Komisarenko MA, Kolisnyk SV, Antonenko OV, Kolisnyk OV, Kostina TA. The study of the qualitative composition and the quantitative content of phenolic compounds in dietary supplements with lingonberry. J Org Pharm Chem. 2021. 19(4(76)). 40-46. DOI: 10.24959/ophcj.21.243782

Maslov O, Kolisnyk S, Komisarenko M, Komisarenko A, Osolodchenko T, Ponomarenko S. In vitro antioxidant and antibacterial activities of green tea leaves (Camella sinensis l.) liquid extracts. AMI. 2022. (2). 64-67. DOI: 10.5281/zenodo.6634846

Maslov OY, Komisarenko MA, Golik MY, Kolisnyk SV, Altukhov AA, Baiurka SV, Karpushina SA, Tkachenko O, Iuliia K. Study of total antioxidant capacity of red raspberry (Rubus idaeous L.) shoots. Vitae. 2023. 30(1). DOI: 10.17533/udea.vitae.v30n1a351486

Maslov OY, Kolisnyk SV, Komisarenko MA, Kolisnyk OV, Ponomarenko SV. Antioxidant activity of green tea leaves (Camellia sinensis L.) liquid extracts. Pharmacologyonline. 2021. (3). 291-298. DOI: 10.5281/zenodo.7813115

Maslov O, Komisarenko M, Ponomarenko S, Horopashna D, Osolodchenko T, Kolisnyk S, Derymedvid L, Shovkova Z, Akhmedov E. Investigation the influence of biologically active compounds on the antioxidant, antibacterial and anti-inflammatory activities of red raspberry (Rubus idaeous l.) leaf extract. Curr Issues Pharm Med Sci. 2022. DOI: 10.2478/cipms-2022-0040

Křížová L, Dadáková K, Kašparovská J, Kašparovský T. Isoflavones. Molecules. 2019. 24(6). 1076. DOI: 10.3390/molecules24061076

Orazbekov Y, Ibrahim MA, Mombekov S, Srivedavyasasri R, Datkhayev U, Makhatov B, Chaurasiya ND, Tekwani BL, Ross SA. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evid Based Complement Altern Med. 2018. 2018. 1-8. DOI: 10.1155/2018/1370368

Barak TH, Kurt Celep İ, Şentürk TB, Bardakcı H, Celep E. Maclura pomifera (Rafin.) Schneider %80 metanol ekstresinin in vitro yaşlanma karşıtı potansiyelinin değerlendirilmesi ve kantitatif HPTLC analizi. Turk J Pharm Sci. 2021. 0. DOI: 10.4274/tjps.galenos.2021.65087

Bourdoux S, Rajkovic A, De Sutter S, Vermeulen A, Spilimbergo S, Zambon A, Hofland G, Uyttendaele M, Devlieghere F. Inactivation of Salmonella, Listeria monocytogenes and Escherichia coli O157:H7 inoculated on coriander by freeze-drying and supercritical CO 2 drying. Innov Food Sci Amp Emerg Technol. 2018. 47. 180-186. DOI: 10.1016/j.ifset.2018.02.007

Izli N, Izli G, Taskin O. Drying kinetics, colour, total phenolic content and antioxidant capacity properties of kiwi dried by different methods. J Food Meas Charact. 2016. 11(1). 64-74. DOI: 10.1007/s11694-016-9372-6

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Опубліковано

2023-07-09

Як цитувати

Маслов, О., Комісаренко , М., Колісник, С., Себій, С., Костіна, Т., Мороз, В., & Ахмедов, Е. (2023). Comparison of chemical composition and antioxidant activity from fresh and dried osage orange (Maclura pomifera) fruits extracts. Анали Мечниковського Інституту, (3), 49–54. https://doi.org/10.5281/zenodo.8324881

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