Дослідження з підбору компонентів для створення лікарського засобу для лікування себорейного дерматиту шкіри голови

Автор(и)

  • Ілона Коноваленко Національний фармацевтичний університет, Україна
  • Альбіна Черкасова Національний фармацевтичний університет, Україна

DOI:

https://doi.org/10.5281/zenodo.10255458

Анотація

Introduction. Seborrheic dermatitis is a chronic recurrent skin disease associated with increased secretion of skin sebum, a change in its qualitative composition, and is characterized by localization in areas of accumulation of sebaceous glands - on the scalp, face, upper body, folds. Scaling of the scalp accompanied by itching creates not only medical, but also social and psychological problems for patients, especially in field military operations, where access to medical supplies and conditions for personal hygiene may be limited, and stress is the main pathogenetic link for exacerbation of seborrheic dermatitis. Therefore, this causes the interest of considering the main aspects of this dermatosis, as well as ensuring high-quality and safe treatment of seborrheic dermatitis in field military conditions and the development of new drugs.

Purpose of the study. The purpose of our research was to conduct an analysis of drugs on the pharmaceutical market of Ukraine and, based on the results, to develop a composition and develop an algorithm for creating a new drug in the form of a mask-balm for the treatment of seborrheic dermatitis of the scalp. Materials and methods. In order to determine the relevance of the creation of new drugs of extemporaneous production, the next stage of research was to analyze literature data. Research methods: information-research, physico-chemical, rheological, organoleptic. Results & Discussion. As a result of the literature analysis of the assortment of dermatological preparations, it was determined that the assortment of medicinal and cosmeceutical preparations manufactured in a pharmacy does not satisfy the needs of the consumer who suffers from manifestations of seborrheic dermatitis of the hairy part of the scalp in full. The selection of the concentration of active pharmaceutical ingredients was justified by literature data on the relativity of the therapeutic effect to its percentage of introduction into the soft dosage form for application purpose. All components are physically and chemically compatible when mixed with each other and exhibit the declared pharmacological effect. It was found that samples with structural viscosity values in the range of (2000 – 10000) mPa·s at 20 rpm have optimal structural and mechanical indicators. The study of the sensory properties of the balm-mask for the treatment of seborrheic dermatitis of the scalp allowed us to choose sample No. 3, which met all the requirements of the regulatory documentation for quality indicators, did not change its properties during storage for 1 month, and satisfied the users' requirements for sensory properties. When analyzing the obtained results, we came to the conclusion that according to the main criteria, the balsam-mask sample obtained meets the requirements of regulatory documentation. Conclusions. 1. The conducted informational and analytical analysis made it possible to establish that, at present, combined drugs for the treatment of seborrheic dermatitis of the scalp of extemporaneous production are presented in insufficient quantities. 2. The development of new multifunctional cosmeceutical preparations for application in the form of a balm-cream containing active substances with complex therapeutic activity (anti-inflammatory, wound healing, antibacterial and mild exfoliating effect) is an urgent task of modern pharmacy. 3. The concentration of zinc-pyrithione, azelaic, glycolic and lactic acids active substances, which would show the claimed effect, was selected. 4. A study was conducted on the selection of auxiliary substances and their concentration. It was determined that the optimal emulsifier is Emulfarma 1000. Rheological and organoleptic (sensory) studies of the obtained experimental samples of balm-cream were carried out.

Keywords: medicine, seboreic dermatitis, scalp

Посилання

Naldi L, Diphoorn J. Seborrhoeic dermatitis of the scalp. BMJ Clin Evid. 2015 May 27;2015:1713. PMID: 26016669; PMCID: PMC4445675.

Li J, Feng Y, Liu C, Yang Z, de Hoog S, Qu Y, Chen B, Li D, Xiong H, Shi D. Presence of Malassezia Hyphae Is Correlated with Pathogenesis of Seborrheic Dermatitis. Microbiol Spectr. 2022 Feb 23;10(1):e0116921. doi: 10.1128/spectrum.01169-21. Epub 2022 Jan 12. PMID: 35019692; PMCID: PMC8754105.

Sei Y. [Seborrheic dermatitis--clinical diagnosis and therapeutic value of different drugs]. Nihon Ishinkin Gakkai Zasshi. 2022;44(2):77-80. Japanese. doi: 10.3314/jjmm.44.77. PMID: 12748587.

Barak-Shinar D, Green LJ. Scalp Seborrheic Dermatitis and Dandruff Therapy Using a Herbal and Zinc Pyrithione-based Therapy of Shampoo and Scalp Lotion. J Clin Aesthet Dermatol. 2018 Jan;11(1):26-31. Epub 2018 Jan 1. PMID: 29410727; PMCID: PMC5788265.

Sobhan M, Gholampoor G, Firozian F, Mohammadi Y, Mehrpooya M. Comparison of efficacy and safety of atorvastatin 5% lotion and betamethasone 0.1% lotion in the treatment of scalp seborrheic dermatitis. Clin Cosmet Investig Dermatol. 2019 Apr 29;12:267-275. doi: 10.2147/CCID.S196412. PMID: 31118730; PMCID: PMC6503294.

Parham S, Kharazi AZ, Bakhsheshi-Rad HR, Nur H, Ismail AF, Sharif S, RamaKrishna S, Berto F. Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials. Antioxidants (Basel). 2020 Dec 21;9(12):1309. doi: 10.3390/antiox9121309. PMID: 33371338; PMCID: PMC7767362.

Pleguezuelos-Beltrán P, Gálvez-Martín P, Nieto-García D, Marchal JA, López-Ruiz E. Advances in spray products for skin regeneration. Bioact Mater. 2022 Mar 8;16:187-203. doi: 10.1016/j.bioactmat.2022.02.023. PMID: 35386328; PMCID: PMC8965724.

N.P. Polovko, L.I. Vyshnevska. Extemporaneous prescriptions for the therapy of dermatological diseases. Tutorial. Х.: NUPh P.h., 2017. 91 p.

Konovalenko I. S., Kriukova A. I., Cherkasova A. O., Herasymova I. V., Yurieva H. B. (2021) Study of the range of the pharmaceutical market of Ukraine medicines for the treatment of seborea dermatitis of the scalp. PharmacologyOnLine, Vol. 3, P. 1474–1479.

Shulga L.I., Bezcenna T.S., Juravel I.O., Piminov O.F. Study of technological parameters of plant raw materials and medicinal forms based on them. Collection of scientific works of employees of NMAPO named after P.L. Shupyka. 2012. Vol. 21, book. 4. P. 490-495.

Cherkasova A. O., Konovalenko I. S. Methodology for the selection of active substances for the creation of a drug for the treatment of seborrheic dermatitis of the scalp. VIII International Scientific Conference of young scientists and students “Prospects for the development of biology, medicine and pharmacy”. Shemkent, Republic of Kazakstan. December 9-10, 2021. P. 4–6.

Baranova І. І., Gladukh Ye. V., Tcelyuba Yu. S. Study of the main technological parameters of the powder of ordinary bodiaga (Spongilla lacustris L.). Current issues of pharmaceutical and medical science and practice. 2010. Vol. XXIII, № 1. P. 11-13.

Trutayev S. І., Tichonov О. І., Schpichak О. S. Determination of technological parameters of medicinal plant raw materials included in complex tincture «Ravisol». Herald of pharmacy. 2008. № 4. P. 39–45.

Vasenda М. М. The current state of production of phytopreparations. Pharmaceutical journal. 2013. № 4. P. 143-147.

Baula О. P., Derkach Т. М. Quality assurance of medicinal products of plant origin: status and prospects. Pharmaceutical journal. 2017. № 2. P.79-78.

Miocinovic J., Miloradovic Z., Josipovic M., Nedeljkovic A. Rheological and textural properties of goat and cow milk set type yoghurts. International Dairy Journal. 2016. Vol. 58. Р. 43-45.

Morell J. L., Claramonte M. D., Vialard A. Validation of a release diffusion cell for topical dosage forms. Int J Pharm. 2016. Vol. 137. Р. 49–55.

Park E. C., Song K. W. Rheological evaluation of petroleum jelly as a base material in ointment and cream formulations: steady shear flow behavior. Pharmacal research archives. 2018. Vol. 33, № 1. Р. 141–150.

Sesto Cabral M. E., Ramos A. N., Cabrera C. A., Valdez J. C. Equipment and method for in vitro release measurements on topical dosage forms. Pharm. Dev. Technol. 2015. Vol. 20, № 5. Р. 619–25.

Shah V. P., Elkins J. S., Williams R. L. Evaluation of the test system used for in vitro release of drugs for topical dermatological drug products. Pharm. Dev. Technol. 2020. Vol. 4, № 3. Р. 377–85.

Shah V. P., Williams R. L. Importance of In Vitro Drug Release. In Topical Drug Bioavailability, Bioequivalence, and Penetration. New York, 2014. Р. 61–67.

The United States Pharmacopoeia. Rockville, 2007. P. 347.

The USP Pharmacists' Pharmacopoeia. 2-nd ed. Rockville, 2018. P. 590

Thomson K. S., Thomson G. K., Biehle J. Novel Topical Combination Ointment with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus, Gram-Negative Superbugs, Yeasts, and Dermatophytic Fungi. Current Therapeutic Research. 2016. Vol. 83. P. 8–12.

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Опубліковано

2023-12-06

Як цитувати

Коноваленко , І. ., & Черкасова , А. . (2023). Дослідження з підбору компонентів для створення лікарського засобу для лікування себорейного дерматиту шкіри голови . Анали Мечниковського Інституту, (4), 133–138. https://doi.org/10.5281/zenodo.10255458

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