Synthesis of cocarboxylase: process intensification via microwave irradiation

Наталия Александровна Пинчукова, Александр Юрьевич Волошко, Николай Юрьевич Горобец, Константин Николаевич Беликов, Людмила Васильевна Гудзенко, Валентин Анатольевич Чебанов

Abstract


Energy saving is the key point in the development of new chemical technologies and industrial scaling of the processes of obtaining chemical reagents, functional materials, pharmaceutical substances, etc. The use of the non-classical process activation methods, including microwave radiation, known as effective heating source, allowing significant process acceleration, is a promising direction in the field of new energy-saving technologies.

The paper gives the results of modeling of the process of synthesis of cocarboxylase - known pharmaceutical substance - in a microwave field. The synthesis includes two stages – preparation of polyphosphoric acid (phosphorylating agent) and phosphorylation of thiamine chloride. The effect of microwave radiation on duration and energy parameters of these processes of various scales (from several grams to several kilograms) was studied. The efficiency of the microwave radiation use at both stages from the point of view of influence on the duration of processes and energy consumption was shown. The effective technique of the preparation of polyphosphoric acid by the method of phosphoric acid dehydration in the microwave field was developed. Optimal parameters of microwave thiamine chloride phosphorylation were found. The comparative assessments of time and energy expenditure in these processes, including taking into account their scaling to the industrial volumes were given for the justification of the economic feasibility of replacing the thermal heating by microwave radiation.

Keywords


microwave radiation; thermal heating, phosphorylation, dehydration; polyphosphoric acid; energy saving; scaling

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Copyright (c) 2014 Наталия Александровна Пинчукова, Александр Юрьевич Волошко, Николай Юрьевич Горобец, Константин Николаевич Беликов, Людмила Васильевна Гудзенко, Валентин Анатольевич Чебанов

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ISSN (print) 1729-3774, ISSN (on-line) 1729-4061