Prospects for using the fruits of Viburnum opulus to obtain medicines of various directions of action

Abstract

Introduction. Viburnum opulus L. is a wild shrub, widely distributed in Europe, North Africa and North Asia. The fruits contain vitamin C, carotenoids, organic acids, iridoids, phenolic compounds, etc. BAC. But, despite the fact that the SPhU 2.4 contains the monograph "Viburnum fruits", the prevalence of the plant in Ukraine and a wide diverse spectrum of pharmacological activity, a medicinal product has not been created yet. Therefore, the aim of this work was conduct an analysis of the domestic pharmaceutical market of raw materials - fruits of Viburnum opulus, products based on them, and to offer several original substances from this type of raw material. Material & methods. The range of viburnum fruits on the domestic pharmaceutical market and products based on it was studied through content analysis of a number of Internet platforms. Fruits of viburnum for the development of the technology for obtaining funds were harvested during 2020-2022 in the Chuguyiv district of the Kharkiv region in the mass fruiting phase. The development of the technology for obtaining liquid and dense extracts was carried out according to generally accepted methods.  Results & discussion. The domestic market contains the raw material fruits of viburnum of 42 domestic producers, products of the food industry (20 products), cosmetic industry (11 products) and 31 dietary supplements, of which 87% are domestically produced. In this regard, we have developed and standardized substances based on fruits of viburnum in the form of liquid and dense extracts, which are at the stage of preclinical research. The liquid extract from the fruits was obtained by maceration of the raw material with 50% ethanol for 48 hours, from which the technology for obtaining “Viburnikor” tablets with cardioprotective action was developed. The dense extract was obtained from fruits of viburnum by extraction with 90% ethanol. The significant content of organic, in particular, phenolcarboxylic acids and anthocyanin aglycones determines the antimicrobial and antioxidant effect, which further involves the creation of gels and sprays for the treatment of inflammatory processes of the oral cavity and skin. Conclusions. Considering the aspects of the biological action of fruits of viburnum, the breadth of their sale in Ukraine, the range of dietary supplements based on them in the domestic pharmaceutical industry, the creation of medicines with antimicrobial, anti-inflammatory, antioxidant, membrane-stabilizing action based on original liquid and dense extracts from fruits of viburnum is promising. Further introduction into the industrial production of pharmaceutical enterprises in Ukraine of tablets with liquid extract "Viburnikor" of cardioprotective action is relevant.