Analysis of specificity of finished forms of antimicrobial preparations from Streptomyces albus

Authors

  • Тетяна Сергіївна Тодосійчук National Technical University of Ukraine “Kyiv Polytechnic Institute”, Peremogy av., 37, Kiev, Ukraine, 03056, Ukraine https://orcid.org/0000-0002-2274-599X
  • Олена Вікторівна Покас State Institution «The L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of NAMS of Ukraine» 5 M. Amosova str., Kiev, Ukraine, 03038, Ukraine https://orcid.org/0000-0002-4062-6011

DOI:

https://doi.org/10.15587/1729-4061.2015.47730

Keywords:

Streptomycesalbus, bacteriolysins, antibiotic, finished forms, antimicrobial activity, antiseptics

Abstract

The antimicrobial activity of the developed experimental forms of antiseptic preparations relatively common infectious agents was investigated. The complex action of the antiseptic solution from Streptomycesalbus UN 44, caused by the activity of bacteriolysins and antibiotic of the strain, defining a wide range of antimicrobial activity was shown. The maximum ability of such an antiseptic to destroy and inhibit the growth of microorganisms is determined in relation to the Gram-positive bacteria of the genera Corynebacterium, Bacillus, Streptococcus, Staphylococcus.

The ability of the strain Streptomycesalbus UN 44 to accumulate an antibiotic in the cell and to secrete it exogenously was revealed. The leading fungistatic antibiotic activity in the finished forms of dry producer biomass and complex liquid antiseptic, the combination of substances with different mechanisms of antimicrobial action in the complex preparation were shown.

Finished forms of antiseptic preparations (solution, extract, dry biomass) for use in veterinary, medicine, canning were proposed.

Author Biographies

Тетяна Сергіївна Тодосійчук, National Technical University of Ukraine “Kyiv Polytechnic Institute”, Peremogy av., 37, Kiev, Ukraine, 03056

Candidate of Technical Sciences, Assistant Professor, Head of the Department

Department of industrial biotechnology

Олена Вікторівна Покас, State Institution «The L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of NAMS of Ukraine» 5 M. Amosova str., Kiev, Ukraine, 03038

Candidate of medical science, Senior Research, head of laboratory

Medical Microbiology Laboratory of the Museum of pathogenic microorganisms to humans

References

  1. Yagafarova, G. G. (2002). Mykroorganizmy – produzenty byologychesky aktyvnuh veshestv. Moscow: Hymyya, 231.
  2. Van Wezel, G. P., McKenzie, N. L., Nodwell, J. R. (2009). Applying the genetics of secondary metabolism in model Actinomycetes to the discovery of new antibiotics. Methods in Enzymol., 458, 117–141. doi: 10.1016/s0076-6879(09)04805-8
  3. Emelda, E. J. (2012). Antimicrobial Activity of Antibiotic Producing Streptomyces macrosporus. IOSR Journal of Pharmacy and Biological Sciences, 2 (3), 20–23. doi: 10.9790/3008-0232023
  4. Postolachi, O., Burteva, S., Derjanschi, V. (2007). Selection of Streptomycetes with antimicrobial activity to the pathogens of bee’s diseases. USAMV-CN., 64 (1-2), 256–259.
  5. Svygak, V. K., Deyneka, S. E. (2014). Antybyotykorezystentnyst:bagatogrannyst problem. Klyn. ta eksper.patologyya, 13 (2(48)), 222–224.
  6. Bassetti, M., Righi, E. (2015). Development of novel antibacterial drugs to combat multiple resistant organisms. Langenbeck’s Archives of Surgery, 400 (2), 153–165. doi: 10.1007/s00423-015-1280-4
  7. Projan, S. J. (2011). Stimulating Antibacterial Research and Development: Sense and Sensibility? Antibiotic Discovery and Development, 1103–1105. doi: 10.1007/978-1-4614-1400-1_37
  8. Ziemska, J., Rajnisz, A., Solecka J. (2013). New perspectives on antibacterial drug research. Centr. Eur. J. of Biol., 8 (10), 943–957.
  9. Coates, A. R. M., Hu, Y. (2006). New Strategies for Antibacterial Drug Design. Drugs in R & D, 7 (3), 133–151. doi: 10.2165/00126839-200607030-00001
  10. Sokolova, I. E., Kylochek, T. P., Vinnikov A. I. (2004). A Biosynthesis activity of Streptomyces recifensis var. lyticus. Mycrobyol. gurn., 66 (6), 10–17.
  11. Alekseenko, O. M., Gernosekova, I. V., Vynnykov A. I. (2011). Vuvchennya vplyvu ekzometabolitiv Streptomyces recifensis var. liticus na ryst gruba Pleurotus ostreatus. Mycrobiol. y bioteh., 2 (14), 41–47.
  12. Gernosekova, I. V., Vynnykov, A. I. (2006). Optumyzatsyja fermentacyjnogo seredovysha rufamyzunostyjkuh mutantyv Streptomyces recifensis var. lуticus za dopomogoyu metodu matematuchnogo planuvannya eksperumentyv. Vysn. Dnyprop. un-tu. Biol., ekol., 1 (14), 67–72.
  13. Romanovska, I. I. (2011). Biotehnologichny aspekty stvorennya immobylyzovannuh na polymernuh nosyjah byologychno aktuvnuh bylkovuh rechovun. Odesa, 39.
  14. Romanovska, I. I., Dekyna, S. S., Martunyuk, N. B. (2009). Immobylyzatsyja proteazu C u biogelj lamydan. Dosjagn. biol. ta med., 2 (14), 25–28.
  15. Zelena, L., Todosiichuk, T., Klochko, V. (2014). Multistage selection of soil actinomycete Streptomyces albus as a producer of antimicrobial substances. Emirates Journal of Food and Agriculture, 27 (3), 250–257. doi: 10.9755/ejfa.v27i3.18267
  16. Todosiichuk, T. S. (2000). Rozrobka tekhnolohii hidrolitychnoho fermentnoho preparatu Cytoretsyfen. Kiev, 25.
  17. Todosiichuk, T. S., Klochko, V. V., Zelena, L. B. (2014). Taxonomic analysis Streptomyces sp. 2435 strain, a producer of antimicrobial substances. Mikrobiol. Zhurn., 76 (1), 3–8.

Downloads

Published

2015-08-18

How to Cite

Тодосійчук, Т. С., & Покас, О. В. (2015). Analysis of specificity of finished forms of antimicrobial preparations from Streptomyces albus. Eastern-European Journal of Enterprise Technologies, 4(6(76), 58–62. https://doi.org/10.15587/1729-4061.2015.47730

Issue

Vol. 4 No. 6(76) (2015): Technology organic and inorganic substances

Section

Technology organic and inorganic substances

License

Copyright (c) 2015 Тетяна Сергіївна Тодосійчук, Олена Вікторівна Покас

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The consolidation and conditions for the transfer of copyright (identification of authorship) is carried out in the License Agreement. In particular, the authors reserve the right to the authorship of their manuscript and transfer the first publication of this work to the journal under the terms of the Creative Commons CC BY license. At the same time, they have the right to conclude on their own additional agreements concerning the non-exclusive distribution of the work in the form in which it was published by this journal, but provided that the link to the first publication of the article in this journal is preserved.

A license agreement is a document in which the author warrants that he/she owns all copyright for the work (manuscript, article, etc.).
The authors, signing the License Agreement with TECHNOLOGY CENTER PC, have all rights to the further use of their work, provided that they link to our edition in which the work was published.
According to the terms of the License Agreement, the Publisher TECHNOLOGY CENTER PC does not take away your copyrights and receives permission from the authors to use and dissemination of the publication through the world's scientific resources (own electronic resources, scientometric databases, repositories, libraries, etc.).
In the absence of a signed License Agreement or in the absence of this agreement of identifiers allowing to identify the identity of the author, the editors have no right to work with the manuscript.
It is important to remember that there is another type of agreement between authors and publishers – when copyright is transferred from the authors to the publisher. In this case, the authors lose ownership of their work and may not use it in any way.