New multifunctional bromine-active polymers: synthesis, properties, and antimicrobial activity

Authors

DOI:

https://doi.org/10.15587/1729-4061.2023.278000

Keywords:

antimicrobial polymers, immobilization, N-bromamines, N-bromosulfonamides, active chlorine, N-bromotaurine, zone of microbial growth inhibition

Abstract

The increase in the frequency and scale of epidemics of infectious diseases gives extreme urgency to the development of new technologies for antiseptic and disinfectant treatment of various media, as well as materials/reagents for their implementation. Antimicrobial polymer materials of various chemical structures, including those containing halogen-active functional groups, are promising in this regard.

This work is devoted to the synthesis and investigation of the properties of granular and fibrous polymer materials with immobilized N-bromosulfonamide groups of different structure. It is shown that copolymers of styrene with divinylbenzene and polypropylene can be used as a carrier polymer. A technique has been developed that allows obtaining polymers with a content of up to 23 % of immobilized active bromine. The compliance of the synthesized materials with the declared structure has been proven by IR spectroscopy and a complex of chemical methods. A decrease in the strength of the obtained polymers compared to the original carriers has been observed, especially in the case of fibers. The stability of the synthesized polymers during storage is lower that of the previously described chlorine-active analogs. For the quantitative determination of active bromine in the target materials, a technique based on its rapid diffusion from the polymer into the taurine solution has been developed. Microbiological research has shown that the synthesized polymers have a pronounced antimicrobial activity, which is higher than that of immobilized N-chlorosulfonamides and is manifested even in the presence of a significant organic load.

The set of investigated characteristics of synthesized polymers with immobilized N-bromosulfonamide groups suggests the prospect of their use as components of antiseptic dressing materials, antimicrobial filters, devices for obtaining antiseptic solutions, and other medical products

Author Biographies

Bohdan Murashevych, Dnipro State Medical University

PhD, Associate Professor

Department of Biochemistry and Medical Chemistry

Dmitry Girenko, Ukrainian State University of Chemical Technology

Doctor of Chemical Sciences, Professor

Department of Physical Chemistry

Mykola Toropin, Ukrainian State University of Chemical Technology

Junior Researcher

Research Institute of Electroplating

Iryna Koshova, Dnipro State Medical University

PhD, Associate Professor

Department of Microbiology, Virology, Immunology, Epidemiology and Medical and Biological Physics and Informatics

Vadym Kovalenko, Ukrainian State University of Chemical Technology

PhD, Associate Professor

Department of Analytical Chemistry and Chemical Technology of Food Additives and Cosmetics

Oleg Lebed, Ukrainian State University of Chemical Technology

PhD, Associate Professor

Department of Biotechnology

Vasyl Chuiko, Dnipro State Medical University

PhD

Department of Obstetrics and Gynecology

Valerii Kotok, Université de Montpellier | CNRS

PhD, Associate Professor

Laboratoire of Charles Coulomb

Dmytro Stepanskyi, Dnipro State Medical University

Doctor of Medical Sciences, Professor

Department of Microbiology, Virology, Immunology, Epidemiology and Medical and Biological Physics and Informatics

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New multifunctional bromine-active polymers: synthesis, properties, and antimicrobial activity

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2023-04-30

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Murashevych, B., Girenko, D., Toropin, M., Koshova, I., Kovalenko, V., Lebed, O., Chuiko, V., Kotok, V., & Stepanskyi, D. (2023). New multifunctional bromine-active polymers: synthesis, properties, and antimicrobial activity. Eastern-European Journal of Enterprise Technologies, 2(6 (122), 32–42. https://doi.org/10.15587/1729-4061.2023.278000

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Vol. 2 No. 6 (122) (2023): Technology organic and inorganic substances

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Technology organic and inorganic substances

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Copyright (c) 2023 Bohdan Murashevych, Dmitry Girenko, Mykola Toropin, Iryna Koshova, Vadym Kovalenko, Oleg Lebed, Vasyl Chuiko, Valerii Kotok, Dmytro Stepanskyi

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