Regularities of obtaining and propertіеs of the hydroxyapatite filled porous composites based on polyvinylpyrrolidone
DOI:
https://doi.org/10.15587/1729-4061.2014.27701Keywords:
porous hydrogels, polyvinylpyrrolidone, silver nanoparticles, hydroxyapatite, bactericidal and fungicidal propertiesAbstract
New hydroxyapatite-filled porous composites based on methacrylic esters and polyvinylpyrrolidone, which can be used in bone regeneration processes were synthesized. The influence of the polymer-monomer composition structure, nature and amount of filler, silver nitrate on the polymerization rate was studied. It was found that with the increase in the amount of polyvinylpyrrolidone in composition, the polymerization rate rises, and the induction period is practically absent. The polymerization rate of compositions of hydrophobic glycidyl methacrylate is significantly higher than in the case of 2-hydroxyethyl methacrylate. Compositions that contain hydroxyapatite in an amount of more than 70 wt. % have lower reactivity compared to the compositions without filler. Adding silver nitrate to the composition reduces the polymerization rate.
The influence of the foam stabilizer nature, hydroxyapatite amount on properties of composites was examined. The porous structure of the material is formed with the content of hydroxyapatite in the original composition of at least 25 wt.%. The highest porosity is observed when using glycerol in an amount of 50 wt. %.
Silver nanoparticles in the form of polyhedra with different sizes in the composite structure were obtained by restoring silver nitrate by tertiary nitrogen of polyvinylpyrrolidone. Formation of silver in this reaction is confirmed by UV spectroscopy and chemical analysis of the products of interaction between AgNO3 and polyvinylpyrrolidone. Synthesized silver-containing composites are characterized by bactericidal and fungicidal properties, in particular regarding the bacteria Escherichia coli, Staphylococcus aureus and Aspergillus niger.References
Pavljychenko, V. H. (2009). Composite polymer hydrogels. Macromolecular compounds, №51(7), 1075-1095.
Suberlyak, O. V., Semenyuk, N. B., Dudok, G. D., Skorokhoda, V. I. (2012, May). Regular trends in synthesis of sorption-active granular copolymers of methacrylic acid esters with polyvinylpyrrolidone. Russian Journal of Applied Chemistry, Vol. 85, № 5, 830–838. http://dx.doi.org/10.1134/s1070427212050254
Hasegawa, S., Tamura, J., Neo, M., Fujibayashi, S., Goto, K., Shikinami, Y., Okazaki, K., et al. (2006). In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-lactide Composite for Bone Substitutes and Scaffolds. KEM. Trans Tech Publications, Vol. 309-311, 1311–1314. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.1311
Chen, F., Lam, W. M., Lin, C. J., Qiu, G. X., Wu, Z. H., Luk, K. D. K., Lu, W. W. (2007, July). Biocompatibility of electrophoretical deposition of nanostructured hydroxyapatite coating on roughen titanium surface: In vitro evaluation using mesenchymal stem cells. J. Biomed. Mater. Res, Vol. 82B, № 1, 183–191. http://dx.doi.org/10.1002/jbm.b.30720
Oliveira, J. M., Salgado, A. J., Sousa, N., Mano, J. F., Reis, R. L. (2010, September). Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies. Progress in Polymer Science, Vol. 35, № 9, 1163–1194. http://dx.doi.org/10.1016/j.progpolymsci.2010.04.006
Malanchuk, V. A. (2010). Nanomedicine and Nanobiotechnology: the application of nanomaterials in dentistry, dental surgery, cranio-maxillofacial, plastic surgery and dental implantation. Scientific Bulletin of National Medical University named after A. A. Bogomoltsa, №1, 169-179.
Gres, A. (2009). Composites based on acrylate copolymers and silver particles. Ukrainian Chemical Journal, №75(5), 55-59.
Semenyuk, N. (2007). Hydroxyapatite filled porous composites for bone replacement. Bulletin of National University "Lviv Polytechnic". Chemistry, Technology materials and their applications, №667, 452-455.
Selyakova, B. (1982). Methods of acrylate and methacrylate analysis. Moscow: Chemistry, 170.
Dubyaha, V. P. (1981). Polymeric membranes. Moscow: Chemistry, 232.
Suberlyak, O. (2004). Complex PVP-Men+ – active сatalyst of vinyl monomers polymerization Polymer materials and their application. Polymer materials and their application, 140-145.
Skorokhoda, V. (2010). Matrix polymerization of 2-hydroxyethylmethacrylate in the presence of polyvinylpirrolidone in permanent magnetic field. Chemistry & Chemical Technology, №4(3), 191-196.
Pyatnytskyy, I. V. (1975). Analytical chemistry of silver. Moscow: Nauka, 264.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2014 Наталія Богданівна Семенюк, Галина Дмитрівна Дудок, Тарас Володимирович Скорохода, Олег Володимирович Суберляк
This work is licensed under a Creative Commons Attribution 4.0 International License.
The consolidation and conditions for the transfer of copyright (identification of authorship) is carried out in the License Agreement. In particular, the authors reserve the right to the authorship of their manuscript and transfer the first publication of this work to the journal under the terms of the Creative Commons CC BY license. At the same time, they have the right to conclude on their own additional agreements concerning the non-exclusive distribution of the work in the form in which it was published by this journal, but provided that the link to the first publication of the article in this journal is preserved.
A license agreement is a document in which the author warrants that he/she owns all copyright for the work (manuscript, article, etc.).
The authors, signing the License Agreement with TECHNOLOGY CENTER PC, have all rights to the further use of their work, provided that they link to our edition in which the work was published.
According to the terms of the License Agreement, the Publisher TECHNOLOGY CENTER PC does not take away your copyrights and receives permission from the authors to use and dissemination of the publication through the world's scientific resources (own electronic resources, scientometric databases, repositories, libraries, etc.).
In the absence of a signed License Agreement or in the absence of this agreement of identifiers allowing to identify the identity of the author, the editors have no right to work with the manuscript.
It is important to remember that there is another type of agreement between authors and publishers – when copyright is transferred from the authors to the publisher. In this case, the authors lose ownership of their work and may not use it in any way.
