Development of the composition and modeling of the properties of the biopolymer system for gel cosmetic products with long-lasting action
DOI:
https://doi.org/10.15587/1729-4061.2025.341368Keywords:
biopolymer system, prolonged delivery, release kinetics, structural and mechanical properties, polyelectrolyte complexAbstract
The object of the study is the properties of a biopolymer system for prolonged delivery of cosmeceutical active ingredients based on natural polysaccharides (sodium hyaluronate and chitosan).
The work solves the problem of the lack of a methodology for predicting the properties of a biopolymer system at the design stage. This methodology should link its component composition with functional and structural-mechanical characteristics. The optimization criterion should be achieving a controlled release profile of the hydrophilic active (dexpanthenol) without an initial "explosive" effect. It was established that the optimal ratio is 2.5% sodium hyaluronate and 1.2% chitosan, which ensures the release of 30–35% of dexpanthenol in 6 hours and 60–65% – in 24 hours. Structural and mechanical analysis confirmed the formation of a stable gel with a viscosity of 9800 ± 250 mPa·s and a storage modulus of 325 Pa. This is explained by the formation of a dense polyelectrolyte network due to electrostatic interactions between the anionic groups of sodium hyaluronate.
The results of the study of the biopolymer system include the development of approximation models. These models predict the release profile of dexpanthenol based on the concentration of polymers and evaluate the structural and mechanical properties of the biopolymer system. The results obtained can be used in the cosmeceutical industry to create gel products with prolonged action. The effectiveness of the system was confirmed in vitro in phosphate buffer solution (pH 7.4; 37°C). The criterion for effectiveness was the achievement of a controlled release profile: 30–35% of the active substance in 6 hours and 60–65% in 24 hours, which provides a long-term effect without an initial “explosive” effect
References
- Putyatin, B., Bliznjuk, O., Masalitina, N., Bezpal’ko, V., Zhukova, L., Filenko, O. et al. (2024). Identifying the influence of the concentration of surfactants on the technological indicators of aerosol emulsion. Eastern-European Journal of Enterprise Technologies, 6 (6 (132)), 6–15. https://doi.org/10.15587/1729-4061.2024.317819
- Felix-Sagaste, K. G., Garcia-Carrasco, M., Picos-Corrales, L. A., Gonzalez-Ruelas, T., Rodriguez-Mercado, J. A. (2023). Plant-animal extracts and biocompatible polymers forming oil-in-water emulsions: Formulations for food and pharmaceutical industries. Hybrid Advances, 3, 100072. https://doi.org/10.1016/j.hybadv.2023.100072
- Kunitsia, E., Popov, M., Gontar, T., Stankevych, S., Zabrodina, I., Stepankova, G. et al. (2024). Determination of the influence of hemp oil-based emulsion systems composition on the oxidation products content during storage. Eastern-European Journal of Enterprise Technologies, 3 (6 (129)), 6–13. https://doi.org/10.15587/1729-4061.2024.304466
- Varanasi, S., Henzel, L., Mendoza, L., Prathapan, R., Batchelor, W., Tabor, R., Garnier, G. (2018). Pickering Emulsions Electrostatically Stabilized by Cellulose Nanocrystals. Frontiers in Chemistry, 6. https://doi.org/10.3389/fchem.2018.00409
- Oleksy, M., Dynarowicz, K., Aebisher, D. (2023). Advances in Biodegradable Polymers and Biomaterials for Medical Applications – A Review. Molecules, 28 (17), 6213. https://doi.org/10.3390/molecules28176213
- Bhattacharjee, A., Chakraborty, A., Mukhopadhyay, G. (2018). Double emulsions – A review with emphasis on updated stability enhancement perspective. World Journal of Pharmacy and Pharmaceutical Sciences, 7 (6), 475–493.
- Tang, J., He, H., Wan, R., Yang, Q., Luo, H., Li, L., Xiong, L. (2021). Cellulose Nanocrystals for Skin Barrier Protection by Preparing a Versatile Foundation Liquid. ACS Omega, 6 (4), 2906–2915. https://doi.org/10.1021/acsomega.0c05257
- Thy, L. T. M., Duy, H. K., Dat, N. M. (2025). Applications of lecithin in emulsion stabilization and advanced delivery systems in cosmetics: A mini-review. Results in Surfaces and Interfaces, 19, 100543. https://doi.org/10.1016/j.rsurfi.2025.100543
- Leonida, M. D., Kumar, I., Song, J., Ocampo, A., Philip, S., Brazuna, R. P., Belbekhouche, S. (2025). Green ethanol-free antisolvent synthesis of zein–chitosan–gum arabic nanocomposites for controlled release of lupulone in topical antioxidant applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 726, 137817. https://doi.org/10.1016/j.colsurfa.2025.137817
- Aydin, T., Gok, B., Budama-Kilinc, Y., Kartal, M. (2025). Obtaining carvacrol from Origanum onites L. essential oil and developing carvacrol-loaded nanoformulation for use in cosmetics. Industrial Crops and Products, 226, 120652. https://doi.org/10.1016/j.indcrop.2025.120652
- Millao, S., Iturra, N., Contardo, I., Morales, E., Quilaqueo, M., Rubilar, M. (2023). Structuring of oils with high PUFA content: Evaluation of the formulation conditions on the oxidative stability and structural properties of ethylcellulose oleogels. Food Chemistry, 405, 134772. https://doi.org/10.1016/j.foodchem.2022.134772
- Pawar, V. U., Dessai, A. D., & Nayak, U. Y. (2024). Oleogels: Versatile Novel Semi-Solid System for Pharmaceuticals. AAPS PharmSciTech, 25 (6). https://doi.org/10.1208/s12249-024-02854-2
- Liu, C., Zheng, Z., Liu, Y. (2022). Effects of natural waxes on the interfacial behavior, structural properties and foam stabilization of aerated emulsions. Food & Function, 13 (17), 8860–8870. https://doi.org/10.1039/d2fo01670b
- Tamarkin, D., Gazal, E., Papiashvili, I., Hazot, Y., Schuz, D., Keynan, R. (2015). Surfactant-free water-free foamable compositions, breakable foams and gels and their uses (U.S. Patent No. US10238746B2). U.S. Patent and Trademark Office.
- Faria-Silva, C., Scavone, D., Marto, J., Carvalheiro, M., Simões, S. (2025). Topical foams containing natural saponins: a world of opportunities in pharmaceutical and cosmetic sciences. Journal of Drug Delivery Science and Technology, 109, 106988. https://doi.org/10.1016/j.jddst.2025.106988
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Copyright (c) 2025 Bogdan Putyatin, Olga Bliznjuk, Volodymyr Panasenko, Anna Belinska, Yana Svishchova, Olena Zolotukhina, Natalia Ashtaeva, Nataliia Masalitina, Inna Zabrodina, Tetiana Kovalova
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